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. 2021 Sep 13;13:193. doi: 10.1007/s40820-021-00717-0

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 11 — a Schematic illustration of the colorimetric biosensing of Hg²⁺ ions using Au nanozyme PAD based on the mercury ion-assisted enhanced catalytic efficiency of Au nanozyme. In the presence of Hg²⁺ ions on the Au nanozyme PAD the catalytic oxidation of TMB enhanced significantly due to the formation of Au–Hg amalgam, resulting in generation of blue colour in the paper-chip. Photograph shows the Au nanozyme PAD with test samples consisting increasing concentration of Hg levels ranging from 0.2–2000 ng. Calibration curve shows the colorimetric response of Au nanozyme PAD-assisted TMB oxidation in the presence of Hg ions [222].

Copyright 2017 Han et al. b Colorimetric biosensor for the detection of proteolytic biomarkers based on unusual peroxidase-mimicking activity of Au nanozymes. Picture shows the naked-eye visualization of colorimetric response with the increasing concentration of protease (0–2.0 mg mL⁻¹) [217]. Copyright 2018 McVey et al.