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. 2021 Aug 31;9:723817. doi: 10.3389/fcell.2021.723817

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Copyright © 2021 Huang, Liu, Zhu, Jin, Chen, Xu, Cheng, Ruan, Su, Meng, Lu and Yan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Identification of gene subtypes based on DEGs in TCGA-BLCA cohort. (A) Consensus clustering of DEGs among three ICI subtypes. (B) Kaplan–Meier curves for OS of the three gene clusters (log-rank test, p < 0.001). (C,D) GO enrichment analysis of the two ICI-related signature genes: ICI signature genes A (C) and ICI signature genes B (D). (E) The fraction of TIICs, immune score and stromal score in three gene clusters (Kruskal–Wallis test, *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001). (F,G) The difference in the expression of PD-L1 (F) and PD-1 (G) among three gene clusters (Kruskal–Wallis test, p < 2.2e-16).