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. 2021 Aug 31;9:723817. doi: 10.3389/fcell.2021.723817

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Copyright © 2021 Huang, Liu, Zhu, Jin, Chen, Xu, Cheng, Ruan, Su, Meng, Lu and Yan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Construction of the ICI score. (A) Alluvial diagram of gene cluster distribution in groups with different ICI score and survival outcomes. (B) The difference in the expression of immune checkpoint-related genes (IDO1, CD274, HAVCR2, PDCD1, CTLA4, and LAG3) and immune activity-related genes (CD8A, CXCL10, CXCL9, GZMA, PRF1, TBX2, and TNF) between high and low ICI score subgroups. (C,D) The gene set enrichment analysis (GSEA) in high (C) and low ICI score subgroups (D). (E) Kaplan–Meier curves for high and low ICI score groups in the TCGA-BLCA cohort (log-rank test, p = 0.002). ***p < 0.001; ****p < 0.0001.