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. 2021 Aug 31;9:700879. doi: 10.3389/fcell.2021.700879

FIGURE 2.

FIGURE 2

Interleukin (IL)-6-stimulated rheumatoid arthritis fibroblast-like synoviocytes (RA-FLS) were sensitive to hypertonic stimulation. Volume changes in FLS on stimulation with a hypertonic solution (400 mOsm/L) pre-treated with or without 50 ng/ml IL-6 for 48 h in (A) RA-FLS, (C) human FLS (HFLS), and (E) osteoarthritis FLS (OA-FLS). The bars represent the mean ± SEM of volume changes with or without IL-6 treatment in (B) RA-FLS, (D) HFLS, and (F) OA-FLS. [***p < 0.001, *: Control vs + (IL)-6]. (G) Volume changes in RA-FLS on stimulation with a hypertonic solution (400 mOsm/L) pre-treated with or without synovial fluid of RA patients for 6 h in a migration assay. (H) The bars represent the mean ± SEM of volume changes with or without synovial fluid of RA patients in RA-FLS. Hypertonic solution (hyper) (n = 3, ***p < 0.001, *: Control vs + RA SF).