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. 2021 Aug 31;12:726895. doi: 10.3389/fphys.2021.726895

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Copyright © 2021 Scalco, Moro, Mongillo and Zaglia.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Optogenetic-based interruption of cardiac arrhythmias. (A) Schematic representation of the potential role of neuronal optogenetics in stopping ventricular arrhythmias. Photostimulation of ArchT with 565 nm light inhibits SNs, leading to significant decrease in arrhythmic events after myocardial ischemia. (B) Representative examples of ischemia-induced ventricular arrhythmias (Vas). (C) Quantitative analysis of the incidence of ischemia-induced VAs showed that optogenetic modulation significantly decreased the number of ventricular premature beats (VPBs). (A–C) Modified with permission from Yu et al. (2017) .