TABLE 3.

Primary and secondary outcomes during weeks 1–12 for groups created by the first randomization: least square (LS) means and their standard errors (SEs), adjusted for baseline and balancing factors used in randomization

Outcome	Reflexology		Meditative practices		Control		p for the difference between reflexology and meditative practices	95% CI
	LS Mean	SE	LS Mean	SE	LS Mean	SE
Average severity of fatigue over weeks 1–4	4.17	0.17	4.08	0.18	4.32	0.26	.72	(−0.36, 0.52)
Average severity of fatigue over weeks 5–12	3.62	0.21	3.53	0.21	3.87	0.28	.73	(−0.42, 0.60)
Severity of fatigue at week 8	3.00	0.29	3.32	0.30	3.70	0.40	.43	(−1.12, 0.49)
Severity of fatigue at week 12	3.77	0.27	3.55	0.28	4.79	0.39	.57	(−0.51, 0.93)
Average summed severity index of other symptoms over weeks 1–4	29.99	1.27	29.32	1.30	32.52	1.87	.68	(−2.52, 3.86)
Average summed severity index of other symptoms over weeks 5–12	26.69	1.66	25.77	1.70	30.25	2.28	.66	(−3.19, 5.04)
Summed severity index of other symptoms at week 8	24.13	1.97	26.38	2.11	27.02	2.81	.42	(−7.72, 3.22)
Summed severity index of other symptoms at week 12	29.80	1.79	30.03	2.86	34.12	2.70	.77	(−5.59, 4.13)
PROMIS anxiety at week 12	52.64	0.84	51.96	0.89	52.96	1.24	.53	(−1.47, 2.83)
PROMIS depression at week 12	51.55	0.79	52.05	0.83	51.40	1.17	.64	(−2.50, 1.53)

Note. LS = least square; SE = standard error; CI = confidence interval; PROMIS = Patient Reported Outcomes Measurement Information System.