Figure 4.

Nasal secretions from patients with CRSwNP display a distinct LM profile to those from both healthy volunteers and URTI patients. (A) Nasal secretions were collected from patients with CRSwNP (n = 16) and healthy volunteers (HV, n = 5) LM concentrations were determined using LC-MS/MS based LM profiling (see methods for details). Differences in LM concentrations were evaluated using PLS-DA. (Left panel) 2-dimensional scores plot and (centre panel) corresponding VIP plot of plasma LM (right panel) loading plot where mediators with VIP score >1 are annotated. (B) Nasal secretions were collected from patients with CRSwNP (n = 16) and patients with URTI (n = 8) LM concentrations were determined using LC-MS/MS based LM profiling (see methods for details). Differences in LM concentrations were evaluated using PLS-DA. (Left panel) 2-dimensional scores plot and (centre panel) corresponding VIP plot of plasma LM (right panel) loading plot where mediators with VIP score >1 are annotated. Shaded areas represent 95% confidence interval (CI), R² = coefficient-of-determination, p = p-value from Hotelling’s T-squared test, dM = Mahalanobis distance between groups.