Table 2.

Neuroanatomical associations of laughter identification in the combined patient cohort.

Contrast	Region	Side	Cluster (voxels)	Peak (mm)			T score	PFWE
				x	y	z
Overall	Inferior frontal gyrus: pars orbitalis	L	119	−34	21	−12	7.29	<.001
	Anterior insula	L	183	−39	4	6	6.37	.002
		R	49	36	8	8	5.77	.010
	Posterior insula	L	18	−40	−6	8	5.61	.016
	Anteromedial prefrontal cortex	L	17	−4	39	40	5.78	.010
	Medio-dorsal thalamus	L	23	0	−16	3	5.69	.013
Mirthful	Inferior frontal gyrus: pars orbitalis	L	2350	−36	21	−10	9.41	<.001
	Anterior insula	R	998	42	21	−6	7.05	<.001
	Dorsal anterior cingulate cortex	L	33	−4	9	44	6.37	.002
	Posterior middle temporal gyrus	L	15	−50	−64	14	5.77	.01
Hostile	Anterior insula	L	267	−39	6	4	7.00	<.001
		R	11	40	3	6	5.46	.002
	Inferior frontal gyrus: pars orbitalis	L	84	−34	20	−12	6.80	<.001
	Posterior insula	R	27	40	−8	10	5.77	.01
	Orbitofrontal cortex	L	14	−33	12	−18	5.63	.015
Posed	Anteromedial prefrontal cortex	L	24	−3	45	28	6.57	<.001
			30	−4	39	40	5.68	.012
	Inferior frontal gyrus: pars orbitalis	L	50	−34	21	−12	6.35	.002
	Anterior cingulate cortex	L	64	−6	40	21	6.10	.003
	Orbitofrontal cortex	L	61	−27	28	−22	5.83	.008
	Anterior insula	L	47	−42	3	3	5.79	.009

Significant regional grey matter associations of overall laughter identification accuracy and unbiased hit rates (see text) for each laughter condition over the combined patient cohort, based on voxel-based morphometry. All clusters with extent larger than 10 voxels are shown. Coordinates of local maxima are in standard Montreal Neurological Institute space. p values were all significant (<.05) after family-wise error (FWE) correction for multiple voxel-wise comparisons over the whole brain.