Table 3.
Comparison of lymphocyte subsets from endometrium or peripheral blood and cytotoxicity of peripheral NK cells among females in different endometriosis subgroups and the control group.
| Ovarian endometriosis (n = 44) | Pelvic endometriosis (n = 57) | Mixed endometriosis (n = 16) | Control (n = 200) | P-value | |
|---|---|---|---|---|---|
| eCD56+ (%) | 11.8 (8.5, 20.8) | 12.0 (7.3, 19.8) | 10.6 (8.1, 16.1) | 12.1 (8.5, 19.1) | 0.893 |
| eCD68+ (%) | 2.0 (1.3, 2.7) | 2.3 (1.6, 3.3) | 2.8 (2.3, 3.1) | 2.1 (1.5, 2.7) | 0.035* |
| eCD1a+ (%) | 0.06 (0.04, 0.09) | 0.07 (0.04, 0.11) | 0.06 (0.03, 0.07) | 0.05 (0.03, 0.10) | 0.424 |
| eCD83+ (%) | 1.6 (1.3, 2.2) | 1.9 (1.1, 2.4) | 2.6 (1.6, 4.1) | 1.7 (1.2, 2.5) | 0.304 |
| eCD57+ (%) | 0.4 (0.2, 0.5) | 0.4 (0.3, 0.6) | 0.3 (0.2, 0.4) | 0.3 (0.2, 0.5) | 0.207 |
| eCD8+ (%) | 2.7 (1.7, 3.9) | 3.1 (2.3, 4.1) | 2.6 (2.1, 3.9) | 3.0 (1.9, 4.2) | 0.626 |
| eFoxP3+ (%) | 0.08 (0.05, 0.11) | 0.11 (0.07, 0.15) | 0.08 (0.06, 0.17) | 0.09 (0.06, 0.13) | 0.082 |
| pCD3+ (%) | 69.1 ± 7.2 | 69.5 ± 6.4 | 70.2 ± 7.8 | 68.4 ± 8.2 | 0.709 |
| pCD3+CD8+ (%) | 26.0 (22.3, 32.0) | 25.7 (23.1, 30.6) | 26.7 (22.0, 30.8) | 25.6 (22.5, 29.8) | 0.984 |
| pCD3+CD4+ (%) | 36.8 ± 6.0 | 37.2 ± 6.6 | 37.3 ± 7.3 | 35.8 ± 6.7 | 0.403 |
| pCD56+CD16+ (%) | 15.9 (9.8, 20.4) | 15.3 (11.9, 21.1) | 15.2 (11.2, 19.8) | 16.9 (11.1, 21.7) | 0.951 |
| pCD19+ (%) | 11.7 (10.4, 15.8) | 13.2 (10.2, 15.0) | 11.8 (8.4, 14.2) | 12.7 (10.5, 15.1) | 0.620 |
| Cytotoxicity at ET25 (%) | 27.6 ± 16.1 | 27.6 ± 14.0 | 20.2 ± 9.9 | 33.3 ± 14.5 | <0.001*** |
| Cytotoxicity at ET50 (%) | 36.7 ± 17.3 | 37.4 ± 14.5 | 29.6 ± 13.1 | 43.4 ± 15.2 | <0.001*** |
e, endometrial cell; p, peripheral blood mononuclear cell; Mixed endometriosis, endometriotic lesions within both the pelvis and ovary.
Cytotoxicity, cytotoxicity of peripheral NK cells, shown as the ratios of target cell lysis. ET, the ratios between effectors and target cells.
Continuous variables with normal distribution: ANOVA, and shown as mean ± standard deviation; continuous variables without normal distribution: Kruskal-Wallis test, and shown as median (interquartile range).
eCD68: Mixed endometriosis versus Control, P = 0.043.
Cytotoxicity at ET25: Ovarian endometriosis versus Control, P = 0.020; Pelvic endometriosis versus Control, P = 0.009; Mixed endometriosis versus Control, P = 0.001.
Cytotoxicity at ET50: Ovarian endometriosis versus Control, P = 0.009; Pelvic endometriosis versus Control, P = 0.010; Mixed endometriosis versus Control, P = 0.001.
*P < 0.05; ***P < 0.001.