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. 2021 Aug 31;11:661288. doi: 10.3389/fonc.2021.661288

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Copyright © 2021 Gao, Li, Liu, Zhang, Gao and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MIR4435-2HG inhibited the growth, metastasis, and epithelial–mesenchymal transition (EMT) of gastric carcinoma cells by mediating miR-138-5p/Sox4 axis. (A) Cell Counting Kit-8 (CCK-8)-8 test was applied to test cell proliferation after co-transfection of si-MIR4435-2HG#1 with anti-miR-138-5p and pcDNA-Sox4 in SGC-7901 and MGC-803 cells. (B, C) Transwell test was applied to test cell invasion and migration after co-transfection of si-MIR4435-2HG#1 with anti-miR-138-5p and pcDNA-Sox4 in SGC-7901 and MGC-803 cells. (D) Flow cytometry was applied to test the cell apoptosis after co-transfection of si-MIR4435-2HG#1 with anti-miR-138-5p and pcDNA-Sox4 in SGC-7901 and MGC-803 cells. Western blotting (WB) was applied to test E-cadherin, vimentin, and fibronectin after co-transfection of si-MIR4435-2HG#1 with anti-miR-138-5p and pcDNA-Sox4 in SGC-7901 and MGC-803 cells. * indicates p < 0.05.