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. 2021 Aug 31;12:721030. doi: 10.3389/fimmu.2021.721030

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Copyright © 2021 Zhang, Wang, A, Qu and Chen

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Genetic alterations of PARP1 and its association with TMB level. Prevalence of PARP1 alterations in variety of tumor types (A); Co-occurrence of genetic mutations in tumors with PARP1 alterations (B); The association between TMB and PARP1 alterations in MSK-IMPACT cohort (C), immune checkpoint inhibitors treatment cohort (D), and microsatellite-stable solid tumors received immune checkpoint inhibitors treatment (E); The association between MSI status and PARP1 alternations in TCGA pan-caner cohorts (F).