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. 2021 Aug 31;12:698045. doi: 10.3389/fimmu.2021.698045

Figure 1.

Figure 1

Reduced viability and increased apoptosis rate of HTR8/SVneo cells was seen in response to high concentrations of inactivated F. nucleatum. Bar graphs represent viability of trophoblast cell lines after stimulation with F. nucleatum normalized to respective controls (A). Representative plots for the analysis of apoptosis rate of HTR8/SVneo, JEG-3 and BeWo cells by flow cytometry (B left). Bar graphs show apoptosis rate of trophoblast cell lines after stimulation with F. nucleatum normalized to respective controls (B right). Normalized data represent the quotient of each value to the mean of untreated controls. Data are presented as mean ± SEM. *padj < 0.05; **padj < 0.01; ***padj < 0.001 as analysed by Repeated Measures ANOVA with Dunnett’s multiple comparison post test, comparing each treatment against the corresponding control. Experiments were performed 6 times in sixtuplicate (A) or in triplicates (B). Each point represents the mean value of the replicates for each experiment. Ctl, control; Fus, ratio of F. nucleatum to cell number.