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. 2021 Aug 31;12:698045. doi: 10.3389/fimmu.2021.698045

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Copyright © 2021 Heusler, Einenkel, Ehrhardt, Muzzio and Zygmunt

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Overview of the schematic effects of rising inactivated F. nucleatum concentrations on HTR8/SVneo. Main results of HTR8/SVneo trophoblastic cells in response to in vitro stimulation with F. nucleatum are summarized. F. nucleatum induced HTR8/SVneo invasion, secretion of soluble mediators (CXCL1, IL-6 and IL-8) and metalloproteinases (MMP-2 and MMP-9). As concentrations of F. nucleatum increased, these did not improve invasiveness, hindered migration, reduced cell viability and induced alterations in the cell cycle.