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. 2021 Aug 31;9:733183. doi: 10.3389/fcell.2021.733183

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Copyright © 2021 Lu, Xu, Zeng, Xue, Li, Chen, Zhou, Lin, Liao, Du, Yang and Zheng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Ex vivo heart perfusion combined with melatonin post-conditioning exerts a profound cardioprotective effect against myocardial IRI in the DCD heart, and this protection appears to be due to the inhibition of NLRP3 inflammasome-mediated pyroptosis. IRI, ischemia/reperfusion injury; DCD, donation after circulatory death.