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. 2021 Aug 31;12:661323. doi: 10.3389/fimmu.2021.661323

Figure 1.

Figure 1

Interkeukin-1β induces pSTAT3(Y705) in human melanoma cells. (A) Mean ± SEM of IL-6 production from 1205Lu cells stimulated with IL-1β after 24 hours (N=3). (B) Mean ± SEM of STAT3/β-actin ratio for 1205Lu cells shown in (A) (N=3). (C) Mean ± SEM of pSTAT3(Y705)/β-actin ratio for 1205Lu cells shown in (A) (N=3). (D) Representative western blot images from (B, C). (E) Mean ± SEM of IL-1β production from unstimulated 1205Lu cells treated with OLT1177 after 48 hours (N=3). (F) Mean ± SEM of IL-6 production from unstimulated 1205Lu cells treated with OLT1177 after 48 hours (N=3). (G) Representative western blot images from (H, I). (H) Mean ± SEM of STAT3/β-actin ratio for 1205Lu cells shown in (G) (N=3). (I) Mean ± SEM of pSTAT3(Y705)/β-actin ratio for 1205Lu cells shown in (G) (N=3). *p < 0.05, ***p < 0.001.