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. 2021 Aug 31;12:661323. doi: 10.3389/fimmu.2021.661323

Figure 2.

Figure 2

NLRP3 inhibition disrupts IL-1β-induced IL-6/STAT3 signaling in the TME. (A) Tumor growth in mice treated with saline control (Vehicle) or OLT1177 (OLT1177) (N=8/group). (B) Mean ± SEM of STAT3/β-actin ratio in primary tumors of mice described in (A) (N=6). (C) Mean ± SEM of pSTAT3(Y705)/β-actin ratio in primary tumors of mice described in (A) (N=6). (D) Representative western blot images from (C, D). (E) Mean ± SEM of relative mRNA expression Il6 from primary tumors. ns (not significant), *p < 0.05, **p < 0.01.