FIGURE 3.

The open field test indicates that Lactobacillus supplementation prevented anxiety-like behavior induced by early life SSE. In the open-field test, the Lactobacillus supplemented group significantly crossed more squares (A), spent more time at central square (B), higher numbers of entries to the center square (C). Values are presented as mean ± SEM. Significant differences between groups are indicated by ***P < 0.001, **P < 0.01; a: con vs. con + Pro; b: MS vs. MS + Pro; c: M + P + S vs. M + P + S + Pro; d: MS+S–M vs. MS+S–M + Pro; NS, not significant.