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. 2021 Aug 31;12:670389. doi: 10.3389/fphar.2021.670389

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Copyright © 2021 Cao, Xu, Chen, Long, Dai, Gui and Lu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Influence of sitagliptin on serum indices in the HFD-fed rats. (A) serum ET-1 levels, n = 3 in each group; (B) serum NO levels, n = 6 in each group; (C) serum SOD levels, n = 6 in each group; (D) serum T-AOC levels, n = 6 in each group; (E) serum FFA levels, n = 6 in each group; (F) serum MDA levels, n = 6 in each group; (G) serum IL-1β levels, n = 3 in each group; (H) serum TNFα levels, n = 3 in each group. SCD: standard chow diet; HFD: high-fat diet; HFD + SIT: HFD and sitagliptin therapy group. All values displayed are mean ± SEM.*p < 0.05, **p < 0.01,***p < 0.001 vs. SCD group; ^# p < 0.05, ^## p < 0.01, ^### p < 0.001 vs. HFD group.