Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Aug 31;12:670389. doi: 10.3389/fphar.2021.670389

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 Cao, Xu, Chen, Long, Dai, Gui and Lu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Effects of sitagliptin on protein expression in PA-treated HUVECs and summary of the main findings in this study. (A) Western blotting results of BCL-2, BAX, IRE1α, GRP78, and CHOP; (B) Quantification analysis of A; (C) Western blotting results of p-eNOS, eNOS, p-JNK and JNK; (D) Quantification analysis of C. All values displayed are means ± SEM of three independent experiments. *p < 0.05, **p < 0.01, ***p < 0.001 vs. CON group; ^&& p < 0.01, ^&&& p < 0.001 vs. PA group; ^% p < 0.05, ^%% p < 0.01 vs. SIT-L group. (E) Proposed mechanism of sitagliptin attenuating HFD/PA-induced endothelial dysfunction and apoptosis possibly by ROS-ER stress-CHOP pathway.