TABLE 2.
Univariate and multivariate COX of prognostic factors in different groups.
| Factors | Univariate COX | Multivariate COX | ||||||
|---|---|---|---|---|---|---|---|---|
| HR | 95% CI lower | 95% CI upper | p value | HR | 95% CI lower | 95% CI upper | p value | |
| All patients in TCGA (n = 322) | ||||||||
| Age | 1.031 | 1.010 | 1.053 | 0.004 | 1.043 | 1.021 | 1.066 | <0.001 |
| Gender | 1.330 | 0.828 | 2.134 | 0.238 | 1.149 | 0.698 | 1.891 | 0.584 |
| T | 3.555 | 2.155 | 5.864 | <0.001 | 2.897 | 1.601 | 5.240 | <0.001 |
| N | 1.898 | 1.438 | 2.506 | <0.001 | 1.132 | 0.804 | 1.595 | 0.477 |
| M | 4.484 | 2.740 | 7.337 | <0.001 | 2.985 | 1.603 | 5.559 | 0.001 |
| Risk score | 1.228 | 1.161 | 1.300 | <0.001 | 1.196 | 1.127 | 1.269 | <0.001 |
| Model group (n = 162) | ||||||||
| Age | 1.024 | 0.996 | 1.053 | 0.094 | 1.033 | 1.002 | 1.065 | 0.038 |
| Gender | 0.734 | 0.393 | 1.369 | 0.331 | 0.758 | 0.388 | 1.480 | 0.417 |
| T | 2.359 | 1.235 | 4.507 | 0.009 | 1.465 | 0.702 | 3.060 | 0.309 |
| N | 1.904 | 1.315 | 2.756 | 0.001 | 1.216 | 0.763 | 1.940 | 0.411 |
| M | 4.654 | 2.451 | 8.838 | <0.001 | 3.405 | 1.500 | 7.726 | 0.003 |
| Risk score | 1.235 | 1.158 | 1.317 | <0.001 | 1.160 | 1.078 | 1.249 | <0.001 |
| Internal validation group (n = 160) | ||||||||
| Age | 1.040 | 1.006 | 1.076 | 0.021 | 1.063 | 1.026 | 1.102 | 0.001 |
| Gender | 3.060 | 1.361 | 6.878 | 0.007 | 2.179 | 0.904 | 5.248 | 0.083 |
| T | 6.649 | 3.078 | 14.362 | <0.001 | 9.612 | 3.662 | 25.230 | <0.001 |
| N | 2.074 | 1.313 | 3.276 | 0.002 | 1.378 | 0.744 | 2.555 | 0.308 |
| M | 4.349 | 1.992 | 9.493 | <0.001 | 2.299 | 0.767 | 6.891 | 0.137 |
| Risk score | 1.178 | 1.033 | 1.343 | 0.015 | 1.250 | 1.088 | 1.436 | 0.002 |
COX: Cox proportional hazard regression analysis.