Table 2.
Harringtonine was effective against HSV-1 infection including five HSV-1 strains.
| Virus | IC50 (μM) | CC50 (μM) | SI | |
|---|---|---|---|---|
| HT | HSV-1 HF | 0.1081±0.013 | 239.6±26.3 | 2,216.47 |
| HSV-1 F | 0.1280±0.011 | 1,871.88 | ||
| HSV-1 Mckrae | 0.1214±0.014 | 1,973.64 | ||
| HSV-1 blue | 0.1320±0.007 | 1,815.15 | ||
| HSV-1 153 | 0.1584±0.009 | 1,512.63 | ||
| ACV | HSV-1 HF | 1.2570±0.081 | >1,000 | >795.54 |
| HSV-1 F | 0.2085±0.016 | >4,796.16 | ||
| HSV-1 Mckrae | 0.5183±0.019 | >1,929.38 | ||
| HSV-1 blue | >50 | Uncertain | ||
| HSV-1 153 | >50 | Uncertain |
IC50, the half maximal inhibitory concentration; CC50, the half maximal cytotoxicity concentration; SI, selectivity index; and CC50/IC50. Values represent the mean±SD of three independent experiments.