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. 2021 Aug 31;12:712139. doi: 10.3389/fphys.2021.712139

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Copyright © 2021 Luo, Chen, Yang, Zhang, Xu and Gou.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MSC treatment reverses the gut microbiota structure in hypoxia-induced PH mice. Feces was collected from Kunming mice at 3 weeks. (A–E) The α-diversity of gut microbiota in normoxia-, hypoxia-induced and MSC-treated mice measured by the Shannon (A), Simpsons (B), Chao1 (C), PD whole tree (D), observed_species (E) indices. ^∗P < 0.05. The results are presented as means ± SEM of 4–7 animals. Chao1 estimates the number of species, whereas Shannon estimates the effective number of species. (F) Rarefaction curves for the observed species in the gut microbiota from normoxia-, hypoxia-induced, and MSC-treated mice. N = 4–7; (G) principal component analysis. NC, normoxia group; Hx, hypoxia-induced group; Hx + MSCs, MSC-treated group.