TABLE 2.
Genotypes and allele frequencies for CYP3A4, CYP3A5, CYP2C9 and CYP2C19 in the study population.
| Genotype | Frequency N (%) | |
|---|---|---|
| CYP3A4*1B (-392A > G) | *1/*1 | 42 (12.3) |
| *1/*1B | 143 (42.1) | |
| *1B/*1B | 155 (45.6) | |
| CYP3A5*3 (c.6986A > G) | *1/*1 | 244 (71.8) |
| *1/*3 | 84 (24.7) | |
| *3/*3 | 12 (3.5) | |
| CYP3A5*6 (c.14690G > A) | *1/*1 | 192 (56.5) |
| *1/*6 | 130 (38.2) | |
| *6/*6 | 18 (5.3) | |
| CYP3A5*7 (27,131_27132insT) | *1/*1 | 279 (82.1) |
| *1/*7 | 56 (16.4) | |
| *7/*7 | 5 (1.5) | |
| CYP2C19*2 | *1/*1 | 228 (67.1) |
| *1/*2 | 103 (30.3) | |
| *2/*2 | 9 (2.6) | |
| CYP2C19*3 | *1/*1 | 328 (96.5) |
| *1/*3 | 12 (3.5) | |
| *3/*3 | 0 (0.0) | |
| CYP2C19*17 | *1/*1 | 236 (69.4) |
| *1/*17 | 92 (27.1) | |
| *17/*17 | 12 (3.5) | |
| CYP2C9*2 | *1/*1 | 337 (99.1) |
| *1/*2 | 3 (0.9) | |
| *2/*2 | 0 (0.0) | |
| CYP2C9*3 | *1/*1 | 335 (98.5) |
| *1/*3 | 5 (1.5) | |
| *3/*3 | 0 (0.0) | |
| Allele | Minor allele | Percentage |
| CYP3A4*1B | *1B | 66.7 |
| CYP3A5*3 | *3 | 15.9 |
| CYP3A5*6 | *6 | 24.4 |
| CYP3A5*7 | *7 | 9.7 |
| CYP2C19*2 | *2 | 17.8 |
| CYP2C19*3 | *3 | 1.7 |
| CYP2C19*17 | *17 | 17.1 |
| CYP2C9*2 | *2 | 0.4 |
| CYP2C9*3 | *3 | 0.7 |