TABLE 3.
Comparison of the geometric means of PZQ, trans-4-OH-PZQ concentrations (ng/mL) and metabolic ratio (trans-4-OH-PZQ/PZQ) between CYP450 genotypes using One-way ANOVA.
| Genotype | N | PZQ GM ± SD | p-value | Trans-4-OH-PZQ | p-value | trans-4-OH-PZQ/PZQ | p-value | |
|---|---|---|---|---|---|---|---|---|
| CYP3A4 | *1/*1 | 40 | 249.5 ± 3.3 | 0.88 | 9,299.7 ± 2.1 | 0.99 | 37.2 ± 3.0 | 0.86 |
| *1B carriers | 247 | 258.2 ± 3.6 | 9,289.7 ± 1.9 | 36.0 ± 3.0 | ||||
| CYP3A5 | *1/*1 | 77 | 261.2 ± 3.5 | 0.89 | 9,462.4 ± 1.0 | 0.77 | 36.2 ± 2.8 | 1.00 |
| *3, *6, *7 carriers | 210 | 255.3 ± 3.6 | 9,225.7 ± 1.9 | 36.1 ± 3.1 | ||||
| CYP2C19 | *17 carriers | 79 | 191.9 ± 3.3 | 0.04 | 9,311.1 ± 1.8 | 0.92 | 48.5 ± 3.0 | 0.01 |
| *1/*1 | 109 | 267.9 ± 3.3 | 9,440.6 ± 1.9 | 35.2 ± 2.6 | ||||
| *2, *3 carriers | 99 | 310.5 ± 4.0 | 9,099.1 ± 2.0 | 29.3 ± 3.3 | ||||
| CYP2C9 | *1/*1 | 279 | 258.2 ± 3.5 | 0.68 | 9,246.9 ± 1.9 | 0.37 | 35.7 ± 2.9 | 0.32 |
| *2, *3 carriers | 8 | 214.3 ± 4.6 | 11,350.1 ± 1.6 | 52.9 ± 5.1 | ||||
GM–Geometric mean.