TABLE 6.
Univariate and Multivariate logistic regression analysis for predictors of adverse events.
| Variable | Adverse Events Yes N (%) | Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|---|---|
| cOR (95%) | p-value | aOR (95%) | p-value | |||
| Age (years) | ≤12 | 68 (28.9) | 1.45 (0.85–2.49) | 0.18 | 1.59 (0.90–2.80) | 0.11 |
| >12 | 23 (21.9) | 1 | 1 | |||
| Sex | Male | 38 (23.9) | 1 | 0.26 | ||
| Female | 53 (29.3) | 0.76 (0.47–1.23) | ||||
| Baseline infection intensity | Light | 11 (12.6) | 1 | 1 | ||
| Moderate | 40 (26.3) | 0.22 (0.11–0.47) | ≤0.001 | 0.20 (0.09–0.43) | ≤0.001 | |
| Heavy | 40 (39.6) | 0.55 (0.32–0.93) | 0.03 | 0.50 (0.29–0.87) | 0.01 | |
| Anaemia | Yes | 25 (32.9) | 1.47 (0.85–2.56) | 0.17 | 1.43 (0.80–2.57) | 0.23 |
| No | 66 (25.0) | 1 | 1 | |||
| Stunting (HAZ) | Yes | 28 (24.1) | 0.81 (0.49–1.36) | 0.43 | ||
| No | 63 (28.1) | 1 | ||||
| Wasting (BAZ) | Yes | 8 (23.5) | 0.83 (0.36–1.89) | 0.65 | ||
| No | 83 (27.1) | 1 | ||||
| CYP3A4 | *1/*1 | 12 (28.6) | 1 | |||
| *1B carriers | 79 (26.5) | 0.90 (0.44–1.85) | 0.78 | |||
| CYP3A5 | *1/*1 | 30 (33.0) | 1 | 1 | ||
| *3,*6,*7 Carriers | 61 (67.0) | 0.58 (0.34–0.98) | 0.04 | 0.62 (0.36–1.07) | 0.09 | |
| CYP2C19 | *17 carriers | 21 (23.1) | 1 | |||
| *1/*1 | 39 (42.9) | 1.08 (0.57–2.05) | 0.81 | |||
| *2,*3 carriers | 31 (34.1) | 1.32 (0.71–2.44) | 0.38 | |||
| CYP2C9 | *1/*1 | 89 (97.8) | 1 | |||
| *2,*3 carriers | 2 (2.2) | 0.91 (0.18–4.59) | 0.91 | |||
cOR- Crude odd ratio; aOR–Adjusted odd ratio.