Table 2.

OR models for the combined endpoint of intensive care unit (ICU) care, hospital admission and emergency department (ED) visit and each endpoint separately

Characteristics*	Combined endpoint (ICU, hospitalisation, ED)		ICU care		Hospital admission		ED visit
	Unadjusted OR (95% CI)	Adjusted OR (95% CI)	Unadjusted OR (95% CI)	Adjusted OR (95% CI)	Unadjusted OR (95% CI)	Adjusted OR (95% CI)	Unadjusted OR (95% CI)	Adjusted OR (95% CI)
Engagement type
No virtual engagement	Ref.	Ref.	Ref.	Ref.	Ref.	Ref.	Ref.	Ref.
Telemedicine visits only	0.56 (0.44 to 0.70)	0.80 (0.61 to 1.03)	0.45 (0.28 to 0.71)	0.65 (0.40 to 1.06)	0.57 (0.43 to 0.76)	0.78 (0.58 to 1.05)	1.60 (1.00 to 2.57)	1.34 (0.81 to 2.22)
Survey only	0.38 (0.33 to 0.45)	0.49 (0.41 to 0.59)	0.05 (0.02 to 0.10)	0.07 (0.03 to 0.16)	0.14 (0.10 to 0.19)	0.17 (0.12 to 0.23)	0.37 (0.21 to 0.66)	0.36 (0.20 to 0.65)
Telemedicine and survey	0.17 (0.11 to 0.27)	0.25 (0.16 to 0.41)	0.04 (0.01 to 0.28)	0.06 (0.01 to 0.47)	0.09 (0.04 to 0.20)	0.14 (0.06 to 0.32)	0.85 (0.37 to 1.94)	0.62 (0.25 to 1.55)
Gender
Male	Ref.	Ref.	Ref.	Ref.	Ref.	Ref.	Ref.	Ref.
Female	0.75 (0.68 to 0.83)	0.85 (0.76 to 0.96)	0.56 (0.48 to 0.67)	0.63 (0.52 to 0.76)	0.83 (0.74 to 0.94)	0.96 (0.84 to 1.10)	1.44 (1.08 to 1.92)	1.42 (1.04 to 1.94)
Race
White	Ref.	Ref.	Ref.	Ref.	Ref.	Ref.	Ref.	Ref.
Black	1.16 (1.04 to 1.30)	1.04 (0.92 to 1.18)	1.19 (0.98 to 1.43)	1.02 (0.82 to 1.27)	1.10 (0.96 to 1.25)	1.03 (0.89 to 1.19)	1.85 (1.34 to 2.56)	1.59 (1.14 to 2.24)
Multiple/Others	1.02 (0.80 to 1.29)	1.17 (0.90 to 1.53)	0.89 (0.58 to 1.38)	1.03 (0.64 to 1.65)	1.05 (0.80 to 1.39)	1.22 (0.90 to 1.64)	1.18 (0.58 to 2.42)	0.97 (0.47 to 2.01)
Age†	1.03 (1.03 to 1.04)	1.01 (1.01 to 1.02)	1.04 (1.03 to 1.05)	1.02 (1.01 to 1.03)	1.03 (1.03 to 1.03)	1.01 (1.01 to 1.02)	0.97 (0.96 to 0.98)	0.97 (0.96 to 0.99)
Emergency use authorisation criteria
Age >65	2.99 (2.67 to 3.35)	1.44 (1.18 to 1.76)	3.12 (2.63 to 3.70)	0.96 (0.69 to 1.33)	2.57 (2.27 to 2.92)	1.42 (1.13 to 1.78)	0.30 (0.19 to 0.48)	0.63 (0.33 to 1.19)
Obesity	1.57 (1.42 to 1.75)	1.59 (1.40 to 1.80)	1.82 (1.51 to 2.18)	1.77 (1.43 to 2.19)	1.48 (1.31 to 1.67)	1.51 (1.31 to 1.73)	0.62 (0.47 to 0.82)	0.65 (0.48 to 0.87)
Diabetes mellitus	2.84 (2.54 to 3.17)	1.46 (1.28 to 1.67)	4.34 (3.66 to 5.16)	2.02 (1.64 to 2.47)	1.90 (1.68 to 2.15)	1.06 (0.92 to 1.24)	0.58 (0.41 to 0.83)	0.68 (0.45 to 1.04)
Cardiac disease	3.66 (3.28 to 4.08)	1.97 (1.69 to 2.30)	7.94 (6.12 to 10.31)	3.44 (2.44 to 4.86)	2.76 (2.43 to 3.14)	1.71 (1.43 to 2.04)	0.64 (0.49 to 0.85)	1.19 (0.83 to 1.71)
Lung disease	2.42 (2.16 to 2.72)	1.85 (1.62 to 2.11)	3.40 (2.86 to 4.04)	2.29 (1.88 to 2.78)	1.55 (1.36 to 1.76)	1.19 (1.03 to 1.38)	1.21 (0.89 to 1.64)	1.39 (1.00 to 1.92)
System primary care physician	0.70 (0.63 to 0.77)	0.51 (0.45 to 0.58)	0.82 (0.69 to 0.97)	0.67 (0.55 to 0.82)	0.69 (0.61 to 0.78)	0.59 (0.51 to 0.68)	0.89 (0.67 to 1.17)	1.14 (0.84 to 1.55)

*N=5740 (84% of total cohort) included in the final model.

†Per one-unit increase, all other variables in model are categorical.