Table 1. Univariate and Multivariate Cox Proportional Hazards Regression Analyses of Prognostic Factors for RFS in the Training Cohort.
| Variable | Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | β estimate | P value | |
| Age (>50 vs ≤50 y) | 0.751 (0.502-1.124) | .16 | NA | NA | NA |
| Sex (male vs female) | 1.747 (0.879-3.470) | .11 | NA | NA | NA |
| HBV infection (positive vs negative) | 1.261 (0.655-2.428) | .49 | NA | NA | NA |
| HCV infection (positive vs negative) | 2.141 (0.298-15.380) | .45 | NA | NA | NA |
| Platelet count (>100 × 103/μL vs ≤100 × 103/μL) | 1.200 (0.623-2.310) | .59 | NA | NA | NA |
| Albumin level (>3.5 vs ≤3.5 g/dL) | 2.276 (0.924-5.606) | .07 | NA | NA | NA |
| Total bilirubin level (>1.0 vs ≤1.0 mg/dL) | 0.966 (0.590-1.581) | .89 | NA | NA | NA |
| AFP level in ng/mL (ln) | 1.071 (1.007-1.139) | .03 | NA | NA | NA |
| Prothrombin time (>13.5 vs ≤13.5 s) | 1.190 (0.484-2.929) | .71 | NA | NA | NA |
| Neutrophil count (>6300/μL vs ≤6300/μL) | 1.442 (0.769-2.705) | .25 | NA | NA | NA |
| WBC count (>10 × 103/μL vs ≤10 × 103/μL) | 0.965 (0.392-2.376) | .94 | NA | NA | NA |
| CRP level (>0.3 vs ≤0.3 mg/dL) | 1.661 (1.108-2.491) | .01 | NA | NA | NA |
| ALT level (>40 vs ≤40 U/L) | 1.289 (0.864-1.925) | .21 | NA | NA | NA |
| AST level (>35 vs ≤35 U/L) | 1.420 (0.949-2.127) | .09 | NA | NA | NA |
| Liver cirrhosis (present vs absent) | 1.200 (0.794-1.814) | .39 | NA | NA | NA |
| Child-Pugh grade (B vs A) | 1.614 (0.225-11.602) | .63 | NA | NA | NA |
| VETC (positive vs negative) | 2.349 (1.554-3.553) | <.001 | 1.853 (1.203-2.855) | 0.617 | .005 |
| MVI (positive vs negative) | 2.628 (1.756-3.933) | <.001 | 1.780 (1.146-2.766) | 0.577 | .01 |
| No. of tumors (multiple vs single) | 2.666 (1.626-4.371) | <.001 | 2.537 (1.533-4.200) | 0.931 | <.001 |
| Maximum tumor size in cm (ln) | 2.266 (1.561-3.290) | <.001 | 1.714 (1.170-2.511) | 0.539 | .006 |
| Tumor differentiation (poor/moderate vs well) | 2.615 (1.063-6.436) | .04 | NA | NA | NA |
| Anatomical resection (yes vs no) | 1.606 (1.050-2.458) | .03 | NA | NA | NA |
| Surgical margin (>1 vs ≤1 cm) | 0.822 (0.539-1.252) | .36 | NA | NA | NA |
Abbreviations: AFP, α-fetoprotein; ALT, alanine aminotransferase; AST, aspartate aminotransferase; CRP, C-reactive protein; HBV, hepatitis B virus; HCV, hepatitis C virus; HR, hazard ratio; ln, log normal; MVI, microvascular invasion; NA, not applicable; RFS, recurrence-free survival; VETC, vessels encapsulating tumor clusters; WBC, white blood cell.
SI conversion factors: To convert albumin to g/L, multiply by 10; ALT and AST to μkat/L, multiply by 0.0167; bilirubin to μmol/L, multiply by 17.104; CRP to mg/L, multiply by 10; neutrophil count and WBC to ×109/L, multiply by 0.001; platelets to ×109/L, multiply by 1.0.