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. 2021 Sep 13;4(9):e2121937. doi: 10.1001/jamanetworkopen.2021.21937

Table 3. Outcomes of Children With SS Who Had Not Yet Undergone Surgery.

Domain and comparison data Standardized mean group differences Prevalence rates
Studies, No. Participants with SS, No. Hedges g (95% CI) P value I 2 τ N fs Studies, No. Participants with SS, No. Prevalence (95% CI)
General cognition
Peers 3 89 −0.28 (−0.67 to 0.10) .15 34.48 0.21 1 1 27 0.37 (0.21 to 0.56)
Normsa 4 160 −0.15 (−0.89 to 0.60) .70 94.99 0.74 0
Motor functioning
Peers 3 108 −0.42 (−0.67 to −0.18) <.001 0.00 0.00 3 2 114 0.17 (0.07 to 0.36)
Norms 4 166 −0.30 (−10.01 to 0.41) .41 94.80 0.71 2
Verbal abilities
Peers 3 99 0.01 (−0.24 to 0.26) .96 0.00 0.00 0 2 90 0.13 (0.03 to 0.40)
Norms 2 103 0.17 (−0.03 to 0.37) .09 0.00 0.00 0
Visuospatial abilities
Peers 1 28 −0.09 (−0.61 to 0.43) .73 NA NA NA 1 87 0.07 (0.03 to 0.15)
Norms 1 26 0.44 (0.04 to 0.83) .03 NA NA NA
Adaptive and social skills
Peers 1 28 −0.21 (−0.72 to 0.31) .44 NA NA NA 1 87 0.06 (0.02 to 0.13)
Norms 1 26 0.21 (−0.60 to 0.18) .30 NA NA NA
Global development
Peers 1 28 −0.31 (−0.83 to 0.21) .25 NA NA NA 5 378 0.15 (0.09 to 0.24)
Norms 1 26 0.30 (−0.09 to 0.70) .13 NA NA NA

Abbreviations: NA, not applicable; Nfs, Orwin failsafe N; SS, sagittal synostosis.

a

Norms refers to comparisons against normative data for each measure.