Summary of findings 6. Surface‐modified versus standard double‐lumen catheter with identical geometry and flow design for preventing clotting of extracorporeal circuits during CKRT.
| Surface‐modified versus standard double‐lumen catheter with identical geometry and flow design for preventing clotting of extracorporeal circuits during CKRT | |||||
| Patient or population: AKI patients receiving CKRT Setting: ICU Intervention: surface‐modified double‐lumen catheter Comparison: standard double‐lumen catheter with identical geometry and flow design | |||||
| Outcomes | Anticipated absolute effects* (95% CI) | Relative effect (95% CI) | No. of participants (studies) | Certainty of the evidence (GRADE) | |
| Risk with standard double‐lumen catheter with identical geometry and flow design | Risk with surface‐modified, double‐lumen catheter | ||||
| Circuit lifespan | The mean circuit lifespan with standard double‐lumen catheters was 118 hours | The mean circuit lifespan with surface‐modified double‐lumen catheters was 16 hours higher (13.49 to 18.51 higher) than standard double‐lumen catheters | ‐‐ | 262 (1) | ⊕⊕⊝⊝ Low 1,2 |
| Death from any cause at day 28 of follow‐up | 331 per 1,000 | 357 per 1,000 (251 to 506) | RR 1.08 (0.76 to 1.53) | 236 (1) | ⊕⊕⊝⊝ Very low 1,2,3 |
| Recovery of kidney function | 492 per 1,000 | 447 per 1,000 (344 to 590) | RR 0.91 (0.70 to 1.20) | 236 (1) | ⊕⊕⊝⊝ Low 1,2 |
| Vascular access complications | 76 per 1,000 | 25 per 1,000 (7 to 92) | RR 0.33 (0.09 to 1.20) | 236 (1) | ⊕⊕⊝⊝ Low 1,2 |
| *The risk in the intervention group (and its 95% CI) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). a we calculated circuit lifespan per circuit CKRT: continuous kidney replacement therapy; AKI: acute kidney injury; ICU: intensive care unit; CI: confidence interval; RR: risk ratio | |||||
| GRADE Working Group grades of evidence High certainty: We are very confident that the true effect lies close to that of the estimate of the effect Moderate certainty: We are moderately confident in the effect estimate: The true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different Low certainty: Our confidence in the effect estimate is limited: The true effect may be substantially different from the estimate of the effect Very low certainty: We have very little confidence in the effect estimate: The true effect is likely to be substantially different from the estimate of effect | |||||
1 Downgraded one level due to serious risk of bias
2 Downgraded one level due to serious imprecision
3 Downgraded one level due to serious indirectness (used ICU mortality as a surrogate)