Summary of findings 8. Flat plate versus hollow fibre filter of the same membrane type for preventing clotting of extracorporeal circuits during CKRT.
| Flat plate versus hollow fibre filter of the same membrane type for preventing clotting of extracorporeal circuits during CKRT | |||||
| Patient or population: people with AKI receiving CKRT Setting: ICU Intervention: flat plate filter Comparison: hollow fibre filter (of the same membrane type) | |||||
| Outcomes | Anticipated absolute effects* (95% CI) | Relative effect (95% CI) | No. of participants (studies) | Certainty of the evidence (GRADE) | |
| Risk with hollow fibre filter of the same membrane type | Risk with flat plate filter | ||||
| Circuit lifespan | The mean circuit lifespan with hollow fibre filters was 17.1 hours | The mean circuit lifespan with flat plate filters was 1.4 hours lower (12.12 lower to 9.32 higher) than hollow fibre filters | ‐‐ | 38 (1) | ⊕⊝⊝⊝ Very low 1,2 |
| Death from any cause at day 28 of follow‐up | Not reported | Not reported | ‐‐ | ‐‐ | ‐‐ |
| Recovery of kidney function | Not reported | Not reported | ‐‐ | ‐‐ | ‐‐ |
| Vascular access complications | Not reported | Not reported | ‐‐ | ‐‐ | ‐‐ |
| *The risk in the intervention group (and its 95% CI) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CKRT: continuous kidney replacement therapy; AKI: acute kidney injury; ICU: intensive care unit; CI: confidence interval; RR: risk ratio | |||||
| GRADE Working Group grades of evidence High certainty: We are very confident that the true effect lies close to that of the estimate of the effect Moderate certainty: We are moderately confident in the effect estimate: The true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different Low certainty: Our confidence in the effect estimate is limited: The true effect may be substantially different from the estimate of the effect Very low certainty: We have very little confidence in the effect estimate: The true effect is likely to be substantially different from the estimate of effect | |||||
1 Downgraded one level due to serious risk of bias
2 Downgraded two levels due to very serious imprecision