Maxvold 2000.

Study characteristics
Methods	Publication type: full article Study design: cross‐over RCT Follow‐up period: not reported Duration of study: not reported
Participants	Country: USA Setting: single centre/paediatric ICU ICU: yes Number: 6 Mean age ± SD: 131.5 ± 81.2 months Sex (M/F): 2/4 Severity: not report Cause of AKI (number): sepsis (2), other (4) Inclusion criteria: unclear, paediatrics undergoing CKRT Exclusion criteria: not reported
Interventions	Treatment group CVVH Control group CVVHD
Outcomes	Death within observation period was reported; however, the number of deaths in each group was not reported due to the cross‐over design
Notes	Funding sources: unclear We could not extract data from the first period (before crossing over)
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Insufficient information to permit judgement
Allocation concealment (selection bias)	Unclear risk	Insufficient information to permit judgement; study protocol was not available
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	Insufficient information to permit judgement
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Insufficient information to permit judgement
Incomplete outcome data (attrition bias) All outcomes	Low risk	No missing outcome data
Selective reporting (reporting bias)	Unclear risk	Insufficient information to permit judgement; study protocol was not available
Other bias: baseline imbalance	Low risk	Cross‐over study; we could not assess baseline imbalance
Other bias: co‐interventions	Unclear risk	insufficient information to permit judgement