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. 2021 Sep 14;2021(9):CD010216. doi: 10.1002/14651858.CD010216.pub6

Comparison 5. Higher versus lower nicotine content.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
5.1 Smoking cessation 1   Risk Ratio (M‐H, Fixed, 95% CI) Totals not selected
5.2 Serious adverse events 2   Risk Ratio (M‐H, Fixed, 95% CI) Totals not selected
5.2.1 1 year 1   Risk Ratio (M‐H, Fixed, 95% CI) Totals not selected
5.2.2 6 months 1   Risk Ratio (M‐H, Fixed, 95% CI) Totals not selected
5.3 Carbon monoxide (ppm) 2 309 Mean Difference (IV, Fixed, 95% CI) ‐0.90 [‐1.70, ‐0.10]
5.3.1 12 weeks 1 155 Mean Difference (IV, Fixed, 95% CI) ‐0.20 [‐1.82, 1.42]
5.3.2 6 months 1 154 Mean Difference (IV, Fixed, 95% CI) ‐1.13 [‐2.05, ‐0.21]
5.4 Heart rate 1   Mean Difference (IV, Fixed, 95% CI) Totals not selected
5.4.1 12 weeks 1   Mean Difference (IV, Fixed, 95% CI) Totals not selected
5.5 Systolic blood pressure 1   Mean Difference (IV, Fixed, 95% CI) Totals not selected
5.5.1 12 weeks 1   Mean Difference (IV, Fixed, 95% CI) Totals not selected
5.6 FeNO (ppb) 1   Mean Difference (IV, Fixed, 95% CI) Totals not selected
5.6.1 12 weeks 1   Mean Difference (IV, Fixed, 95% CI) Totals not selected
5.7 FEV1 (l) 1   Mean Difference (IV, Fixed, 95% CI) Totals not selected
5.7.1 12 weeks 1   Mean Difference (IV, Fixed, 95% CI) Totals not selected
5.8 FVC (l) 1   Mean Difference (IV, Fixed, 95% CI) Totals not selected
5.8.1 12 weeks 1   Mean Difference (IV, Fixed, 95% CI) Totals not selected
5.9 FEV1/FVC 1   Mean Difference (IV, Fixed, 95% CI) Totals not selected
5.9.1 12 weeks 1   Mean Difference (IV, Fixed, 95% CI) Totals not selected
5.10 NNAL (pg/mg creatinine) at 24 weeks 1   Mean Difference (IV, Fixed, 95% CI) Totals not selected
5.11 Product use at 6+ months 1   Risk Ratio (M‐H, Fixed, 95% CI) Totals not selected