NCT04238832.

Study name	Impact of non‐cigarette tobacco product formulation on reinforcement value and use in current smokers Short title: Salt‐Based E‐cigarette
Methods	RCT Setting: USA, South Carolina
Participants	30 participants Inclusion criteria: daily cigarette smoker interested in using non‐cigarette tobacco product have a smartphone that can receive text messages and has access to the internet or have an e‐mail account they check daily (necessary for daily diary completion) Exclusion criteria: additional tobacco use criteria additional medical criteria
Interventions	Salt base nicotine Free base nicotine
Outcomes	Most preferred product [ Time Frame: Lab Visit 2, occurring approximately 1 week after the initial screening/baseline visit ] Participants complete a preference assessment in which they choose between the salt liquid, free‐base liquid, or a traditional cigarette in a series of trials. The outcome of this assessment is the product chosen most often by each participant Cigarettes per day [ Time Frame: Week 2 of study ] The average number of cigarettes smoked per day during the 1 week sampling period. Biomarkers (i.e. expired CO, cotinine) will corroborate self‐reported indices of use
Starting date	23 June 2020. Estimated completion August 2021
Contact information	Tracy Smith, smithtra@musc.edu
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