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. 2021 Sep 2;22(5):1244. doi: 10.3892/etm.2021.10679

Figure 2.

Figure 2

LINC01385 knockdown decreases the concentration of inflammatory factors and increases cell viability in the IL-1β-induced HC-a. (A) The mRNA expression level of LINC01385 following transfection with sh-LINC01385 or pcDNA-LINC01385 and their respective NCs into the HC-a was detected using reverse transcription-quantitative PCR. ***P<0.001 vs. the sh-NC group. ###P<0.001 vs. the pcDNA3.1 group. (B) The viability of the IL-1β-induced HC-a was measured using a MTT assay. ***P<0.001 vs. the Control group. ##P<0.01 vs. the IL-1β + sh-NC group; &&P<0.01 vs. the IL-1β + pcDNA3.1 group. The concentration of (C) IL-6, (D) TNF-α and (E) PGE2 in IL-1β-induced HC-a was measured using ELISA. ***P<0.001 vs. the Control group. ###P<0.001 vs. the IL-1β + sh-NC group. &&&P<0.001 vs. the IL-1β + pcDNA3.1 group. NC, negative control; sh, short hairpin; OD, optical density; TNF, tumor necrosis factor; PGE2, prostaglandin E2.