Figure 4.

Intermediate inflammatory states define the majority of MPM TIMEs. Area under the curve denotes estimated frequency of TIME phenotypes. Quantitative and spatial immunophenotyping data suggest most MPM TIMEs bear the ‘altered’ phenotype, while hot tumors are uncommon and cold tumors are rare. TAMs, particularly M2-like TAMs, T_regs and MDSCs suppress infiltrated tumors, while TAMs and T_regs can actively exclude cytotoxic T lymphocytes. MDSC, myeloid-derived suppressor cell; MPM, malignant pleural mesothelioma; TAM, tumor-associated macrophage; TIME, tumor immune microenvironment; T_reg, regulatory T lymphocyte.