Fig. 6.
Free-fatty acid repector-2 knock-out mice are not protected from DNBS-induced colitis by infection with H. diminuta. Male ffar2−/− mice and ffar2+/− littermates were infected with 5 cysticercoids of H. diminuta (H. dim) and 8 days later were challenged with di-nitrobenzene sulphonic acid (DNBS, 3 mg, ir). At necropsy 72 h post-DNBS, disease was assessed by A disease activity and B histopathology scores and colon length (C). D Isolated splenocytes (5 × 106/mL) were stimulated with concanavalin-A (2 μg/ml) for 48 h and il-10 production measured by ELISA (data are mean ± SEM combined data from 2 experiments; * and #, p < 0.05 compared to control and DNBS-only in the matched mouse strain)