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. 2021 Sep 12;9(9):e002754. doi: 10.1136/jitc-2021-002754

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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T-cell activation and dysfunction of enriched SYTL4-TIL1-iRFP and KIF2C-PBC1-iRFP TCR on neoantigen stimulation with MG-transduced U-698-M. (A) IFN-γ secretion of T cells 24 hours after coculture. (B–E) Expression of specific markers 24 hours after coculture: percentage of T-bet⁺ cells within CD8⁺ T cells (B), MFI for T-bet of CD8⁺ T cells (C), percentage of PD-1⁺ cells within CD8⁺ T cells (D) and MFI for PD-1 of CD8⁺ T cells (E). (F, J) T-cell activation and dysfunction was comparably assessed 24 hours after second stimulation of SYLT4-TIL1-iRFP and KIF2C-PBC2-iRFP transgenic T cells with MG-expressing target cells at day 11 after initial stimulation. Results of transduced T cells from three different donors are shown. MG, minigene; PD-1, programmed cell death protein 1; TCR, T-cell receptor.