Table 3.

Barcelona-Clínic Liver Cancer (BCLC) classification with stage definitions and typical survival outcomes

	Stage definition (BCLC 2018 update)	Estimated survival
Stage 0—Very early-stage	Single nodule ≤2 cm; ECOG PS 0*; Preserved liver function	>5 years
			Stage A—Early-stage	Single or up to three nodules ≤3 cm; ECOG PS 0*; Preserved liver function	>5 years
						Stage B—Intermediate-stage	Multinodular; ECOG PS 0*; Preserved liver function	>2 to 5 years
Stage C—Advanced-stage	Portal invasion; Extrahepatic spread; ECOG PS 1–2; Preserved liver function	>1 year
Stage D—Terminal-stage	ECOG PS 3–4; End-stage liver function	3 months

*The American Association for the Study of Liver Disease (AASLD) recommends including ECOG PS 0 to 1 in stage 0, A and B, because of the significant overlap between PS 0 and PS 1

BCLC, Barcelona-Clinic Liver Cancer; ECOG, Eastern Cooperative Oncology Group; PS, performance status.