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. 2021 Sep 12;9(9):e002737. doi: 10.1136/jitc-2021-002737

Figure 4.

Figure 4

SINV-CAR targeted with tFab suppresses tumor growth in spleen. (A) Mice engrafted with FFLuc BV-173 tumor cells and treated with either SINV-CAR alone or SINV-CAR plus tFab were euthanized, and spleens were weighed (right, n=10, mean shown). Representative images of the spleens (left panel). ***P=0.0002, unpaired t-test. (B) Representative flow plots (left panel) and summary (right panel) of the percentage of human CD19+ tumor B cells infiltrating the spleen of mice engrafted with FFLuc BV-173 and treated with either SINV-CAR alone or SINV-CAR plus tFab at time of sacrifice (n=10, mean shown). ****P<0.0001, unpaired t-test. (C) Representative flow plots (left panel) and quantification (right panel) of human CAR-T cells (gated on CD3+CD45+) in the spleen at the time of euthanasia (n=10 each condition, mean shown). Empty symbols denote the flow plots shown to the left. *P=0.0293, unpaired t-test. CAR, chimeric antigen receptor; tFab, tandem Fab format.