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. 2021 Sep 13;21:433. doi: 10.1186/s12872-021-02228-7

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 8 — Antagonistic effect of CS overexpression on ABCA1 inhibition. A, B the levels of ABCA1 and CS mRNA and protein expression in response to transfections. The original bands of WB are presented in Additional file 1: [2C]. C the cellular cholesterol efflux from VECs. D the levels of cellular CS, IL-6, and TNF-α in VECs. Ox-LDL, oxidized low-density lipoprotein. NC, overexpression negative control. **p < 0.01 vs. control by one-way ANOVA followed by Tukey's post hoc test. ^&&p < 0.01 vs. ox-LDL by one-way ANOVA followed by Tukey's post hoc test. ^##p < 0.01 vs. OE-ABCA1 by one-way ANOVA followed by Tukey's post hoc test. The above experiments were repeated three times and the mean value was obtained