Table 4.

Genes with the highest degrees from the modules associated with FRC exposure (Modules 2, 7, and 10)

Module	Degree	Gene	Name	Known function in zebrafish from previous studies	Reference
2	32	mxd1	Max Dimerization Protein 1	unknown
	31	zgc.158689	unidentified	unknown
	30	osbpl2a	oxysterol binding protein-like 2a	unknown
	30	srgap3	Slit-Robo GTPase activating protein 3	role in neurodevelopmental processes	[46]
	30	tfe3a	Transcription factor-binding to IGHM enhancer 3a	Part of the MiT family coding for basic-helix-loop-helix/leucine zipper class transcription factors	[47]
	30	cacna1da	calcium channel, voltage-dependent, L type, alpha 1D subunit, a	calcium channel-related gene whose expression was shown to be altered by triadimefon, a broad-spectrum fungicide, and silica nanoparticle exposures to embryonic zebrafish	[48, 49]
7	18	NA_1170	uncharacterized
	12	purab	Purine-rich element-binding protein Ab	unknown
	11	sgsm1a	small G protein signaling modulator 1a	associated with small G protein-mediated signal transduction	[50]
	10	fermt2	fermitin family member 2	part of the Kindlin or Fermitin family of scaffold proteins important for signaling across membrane-spanning integrin adhesion receptors	[51]
10	10	apc2	APC regulator of WNT signaling pathway 2	in the family of genes coding for a regulator of the WNT signaling pathway	[45]
	10	celsr3	cadherin, EGF LAG seven-pass G-type receptor 3	plays a role in the facial motor neuron migration in zebrafish	[52]
	9	adam22	ADAM metallopeptidase domain 22	unknown
	9	NA_108	unidentified	unknown