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. 2021 Sep 14;13:154. doi: 10.1186/s13195-021-00897-2

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Study flow diagram for a phase I protocol in participants with Alzheimer’s disease. A Participants underwent three repeated hUCB-MSC injections in a dose-escalating, open-label fashion with two sequential doses (1.0 × 10⁷ cells/2 mL in the low dose [LD] group and 3.0 × 10⁷ cells/2 mL in the high dose [HD] group). Before continuing the study with subsequent participants, we confirmed that there was no DLT. Empty arrows indicate hUCB-MSC injection. B Schematic drawing of right intracerebroventricular injection of hUCB-MSCs via the Ommaya reservoir