Table 3.
Scores of ADAS-Cog, S-IADL, MMSE, and NPI at each time point
| ` | ADAS-Cog | S-IADL | MMSE | NPI | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Low dose | High dose | Total | Low dose | High dose | Total | Low dose | High dose | Total | Low dose | High dose | Total | ||
| n = 3 | n = 6 | n = 9 | n = 3 | n = 6 | n = 9 | n = 3 | n = 6 | n = 9 | n = 3 | n = 6 | n = 9 | ||
| Screening | Mean ± SD | 15.0 ± 2.0 | 22.5 ± 6.2 | 20.0 ± 6.3 | 9.3 ± 4.0 | 13.0 ± 5.8 | 11.8 ± 5.3 | 24.0 ± 1.7 | 21.3 ± 2.7 | 22.2 ± 2.6 | 10.0 ± 7.8 | 1.5 ± 1.5 | 4.3 ± 5.9 |
| Median | 15 | 23 | 19.7 | 10 | 14.7 | 13 | 24 | 20.7 | 22 | 6 | 1.3 | 2.7 | |
| Min–Max | 13–17 | 12–30 | 12–30 | 5–13 | 5–20 | 5–20 | 22–25 | 18–25 | 18–25 | 5–19 | 0–4 | 0–19 | |
| Baseline | Mean ± SD | 18.0 ± 1.7 | 22.8 ± 6.5 | 21.2 ± 5.8 | 8.3 ± 4.6 | 15.3 ± 5.9 | 13.0 ± 6.3 | 24.0 ± 2.6 | 19.7 ± 4.0 | 21.1 ± 4.1 | 1.0 ± 1.7 | 5.3 ± 8.9 | 3.9 ± 7.4 |
| Median | 18 | 23.5 | 19.5 | 8.3 | 17.5 | 13 | 25 | 19.5 | 21.8 | 1 | 1.5 | 1 | |
| Min–Max | 16–19 | 13–29 | 13–29 | 3–11 | 7–21 | 3–21 | 21–26 | 14–24 | 14–26 | 0–3 | 0–23 | 0–23 | |
| Week 4 | Mean ± SD | 17.3 ± 3.8 | 22.2 ± 5.5 | 20.6 ± 5.3 | 12.3 ± 5.9 | 16.5 ± 9.4 | 15.1 ± 8.2 | 24.3 ± 1.5 | 21.5 ± 3.3 | 22.4 ± 3.1 | 5.7 ± 2.3 | 3.5 ± 3.6 | 4.2 ± 3.2 |
| Median | 19 | 21.3 | 19.3 | 10 | 15.5 | 12 | 24 | 21.5 | 23.3 | 5.7 | 3 | 4 | |
| Min–Max | 13–20 | 16–29 | 13–29 | 8–19 | 5–28 | 5–28 | 23–26 | 17–25 | 17–26 | 3–7 | 0–9 | 0–9 | |
| Week 8 | Mean ± SD | 15.7 ± 6.1 | 23.2 ± 6.7 | 20.7 ± 7.2 | 10.3 ± 2.1 | 17.8 ± 6.3 | 15.3 ± 6.3 | 26.0 ± 2.0 | 21.5 ± 3.6 | 23.0 ± 3.7 | 5.0 ± 5.6 | 5.3 ± 6.7 | 5.2 ± 6.0 |
| Median | 17 | 24 | 20.3 | 11 | 17.5 | 13 | 26 | 22 | 23.5 | 4 | 4 | 4 | |
| Min–Max | 9–21 | 13–31 | 9–31 | 8–12 | 10–28 | 8–28 | 24–28 | 16–26 | 16–28 | 0–11 | 0–18 | 0–18 | |
| Week 12 | Mean ± SD | 18.7 ± 2.5 | 25.2 ± 8.2 | 23.0 ± 7.4 | 10.3 ± 5.0 | 16.8 ± 6.5 | 14.7 ± 6.6 | 24.0 ± 4.4 | 20.3 ± 3.6 | 21.6 ± 4.0 | 2.3 ± 2.1 | 3.7 ± 6.0 | 3.2 ± 4.9 |
| Median | 19 | 23.5 | 21 | 11 | 17 | 14 | 26 | 20 | 21 | 3 | 3.2 | 2 | |
| Min–Max | 16–21 | 17–36 | 16–36 | 5–15 | 8–26 | 5–26 | 19–27 | 16–25 | 16–27 | 0–4 | 0–14 | 0–14 | |
| Mean change from baseline to week 12 | Mean ± SD | 0.7 ± 4.0 | 2.3 ± 5.0 | 1.8 ± 4.5 | 2.0 ± 2.0 | 1.5 ± 3.0 | 1.7 ± 2.6 | 0.0 ± 2.0 | 0.7 ± 1.6 | 0.4 ± 1.7 | 1.3 ± 2.3 | − 1.7 ± 5.8 | − 0.7 ± 5.0 |
| Median | 0 | 3.5 | 3 | 2 | 1.5 | 1.7 | 0 | 0.5 | 0.3 | 1.3 | − 1.5 | − 0.5 | |
| Min–Max | − 3–5 | − 4–9 | − 4–9 | 0–4 | − 3–6 | − 3–6 | − 2–2 | − 1–3 | − 2–3 | 0–4 | − 9–8 | − 9–8 | |
| Week 52 | n = 1 | n = 5 | n = 6 | n = 1 | n = 5 | n = 6 | n = 1 | n = 5 | n = 6 | n = 1 | n = 5 | n = 6 | |
| Mean ± SD | 19 | 30.0 ± 9.8 | 28.2 ± 9.8 | 17 | 23.4 ± 9.0 | 22.3 ± 8.4 | 23 | 16.0 ± 6.0 | 17.2 ± 6.0 | 41 | 2.6 ± 2.1 | 9.0 ± 15.8 | |
| Median | 19 | 31.0 | 28.5 | 17 | 21 | 19.5 | 23 | 17.0 | 18.5 | 41 | 3.0 | 3.5 | |
| Min–Max | 16–42 | 16–42 | 14–37 | 14–37 | 6–21 | 6–23 | 0–5 | 0–41 | |||||
| Week 104 | n = 0 | n = 4 | n = 4 | n = 0 | n = 4 | n = 4 | n = 0 | n = 4 | n = 4 | n = 0 | n = 4 | n = 4 | |
| Mean ± SD | 35.3 ± 13.6 | 35.3 ± 13.6 | 30.0 ± 9.2 | 30.0 ± 9.2 | 13.3 ± 8.0 | 13.3 ± 8.0 | 0.8 ± 1.0 | 0.8 ± 1.0 | |||||
| Median | 32 | 32 | 31 | 31 | 14 | 14 | 0.7 | 0.7 | |||||
| Min–Max | 23–54 | 23–54 | 18–40 | 18–40 | 3–22 | 3–22 | 0–2 | 0–2 | |||||
ADAS-Cog, Alzheimer’s Disease Assessment Scale-Cognitive Subscale; S-IADL, Seoul Instrumental Activities of Daily Living; MMSE, Mini-Mental State Examination; NPI, neuropsychiatric inventory; hUCB-MSC, human umbilical cord blood–derived mesenchymal stem cell; SD, standard deviation