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. 2021 Sep 14;52:118. doi: 10.1186/s13567-021-00991-1

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Therapeutic effects of microencapsulated phages in vivo. A Survival curves of rats within one week after administration of E. coli. Rats challenged with E. coli O157:H7 (10⁹ CFU/mL, 1 mL/100 g) were gavaged with free or microencapsulated phages (10⁸ PFU/rat) 8 h after infection. Rats in the positive control group were gavaged with E. coli O157:H7 and PBS. Rats in the negative control group received only 2 mL of PBS. Survival rates of the rats in all groups were monitored. B Changes in the weights of the rats within one week after administration of E. coli. The weights of the rats in the free phage, microencapsulated phage and negative control groups were monitored for 1 week. Statistical analysis was used to compare the microencapsulated phage group and the free phage group. ns, no significant difference; *P < 0.05; **P < 0.01.