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. 2021 Sep 14;52:118. doi: 10.1186/s13567-021-00991-1

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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The concentration of WBCs and inflammatory factors in vivo. A Changes in WBCs in rats within 1 week after administration of E. coli. The two dashed lines represent the normal range of WBCs in rats. Changes in B TNF-α, C IL-6 and D IL-1β in rats within one week after administration of E. coli. Each value in the figure represents the mean ± SD (n = 3) with the exception of Figure 4A. Statistical analysis was used to compare the microencapsulated phage group and the free phage group. ns, no significant difference; *P < 0.05; **P < 0.01.