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. 2021 Sep 14;12:502. doi: 10.1186/s13287-021-02453-z

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — In vitro immunomodulatory properties of RA patient-derived SF-MSCs. a Evaluation of inhibited PBMC proliferation. The ratios 1:4, 1:2, and 1:1 indicate the cell population of pre-seeded SF-MSCs and PBMCs. PBMC and PBMC+PHAL indicate PBMC cultures without or with PHAL, respectively. b Comparison of inhibited PBMC proliferation in the highest PBMC to MSC ratio (1:1). c Quantification of IDO secretion after treatment with inflammatory cytokines by ELISA. Con or T indicate cells that were untreated or treated with inflammatory cytokines, respectively. d Evaluation of IDO activity after treatment with IFN-γ by measurement of L-kynurenine. The asterisks indicate significant differences. The data represent mean values ± SD. PBMC, peripheral blood mononuclear cells; PHAL, phytohemagglutinin-L; IDO, indoleamine 2,3-dioxygenase; IFN-γ, interferon-γ