Table 3.

Correlation analysis of DPYSL2 and related genes and immune cells markers in TIMER

Description	Gene markers	Non-adjusted		Tumor purity adjusted
		Cor	P value	Cor	P value
CD4+T cell	CD4	0.425	***	0.412	***
Th1	STAT4	0.154	**	0.106	1.9e−02
	TNF	0.138	*	0.083	6.63e−02
	TBX21	0.105	1.71e−02	0.06	1.8e-01
Th2	STAT5A	0.334	***	0.305	***
	STAT6	0.333	***	0.353	***
	GATA3	0.126	*	0.071	1.17e−01
Tfh	CCL13	0.307	***	0.271	***
	BCL6	0.272	***	0.268	***
	CCR5	0.218	***	0.17	**
Th17	STAT3	0.35	***	0.349	***
	RORC	0.163	**	0.194	***
	IL17A	− 0.094	3.32e−02	− 0.122	*
Treg	STAT5B	0.374	***	0.356	***
	CCR8	0.219	***	0.175	***
	FOXP3	0.133	*	0.08	7.73e−02
T cell exhaustion	HAVCR2	0.225	***	0.187	***
	GZMB	− 0.262	***	− 0.333	***
	CTLA4	0.07	1.15e−01	0.003	9.43e−01
	PDCD1	−0.044	3.19e−01	− 0.113	1.24e−02
CD8+T cell	CD8A	−0.02	6.52e−01	− 0.08	7.73e−02
	CD8B	−0.116	*	− 0.17	**
M1 Macrophage	IRF5	0.15	**	0.118	*
	NOS2	0.13	*	0.116	1e−02
	PTGS2	0.106	1.65e−02	0.115	1.09e−02
M2 Macrophage	MS4A4A	0.306	***	0.28	***
	CD163	0.291	***	0.267	***
	VSIG4	0.241	***	0.215	***
Neutrophil	CEACAM8	0.428	***	0.428	***
	ITGAM	0.383	***	0.362	***
	CCR7	0.266	***	0.229	***
Dendritic cell	CD1C	0.522	***	0.499	***
	HLA-DPB1	0.405	***	0.388	***
	HLA-DPA1	0.401	***	0.382	***
	ITGAX	0.29	***	0.268	***
TAM	CD68	0.234	***	0.212	***
	IL10	0.164	**	0.114	1.13e−02
	CCL2	0.162	**	0.113	1.17e−02
B cell	CD27	0.077	8.08e−02	0.027	5.48e−01
	CD19	0.057	1.94e−01	0.009	8.38e−01
	CD79A	0.052	2.34e−01	0.011	8.11e−01

Cor correlation coefficient; *P < 0.05, **P < 0.01, ***P < 0.001