Table 1.
Baseline characteristics
| Variables | Boston |
Birmingham |
Overall |
|||
|---|---|---|---|---|---|---|
| AKI (n = 14) | No AKI (n = 14) | AKI (n = 8) | No AKI (n = 10) | AKI (n = 22) | No AKI (n = 24) | |
| Age, yr, med (IQR) | 65 (60–72) | 49 (44–67) | 64 (36–69) | 54 (39–58) | 65 (59–70) | 52 (43–65) |
| Female, n (%) | 3 (21.4) | 6 (42.9) | 3 (37.5) | 5 (50.0) | 6 (27.3) | 11 (45.8) |
| Race, n (%) | ||||||
| Asian | 1 (7.1) | 0 (0.0) | 1 (12.5) | 0 (0.0) | 2 (9.1) | 0 (0.0) |
| Black | 3 (21.4) | 2 (14.3) | 5 (62.5) | 4 (40.0) | 8 (36.4) | 6 (25.0) |
| White | 6 (42.9) | 6 (42.9) | 2 (25.0) | 6 (60.0) | 8 (36.4) | 12 (50.0) |
| Other/not known | 4 (28.6) | 6 (42.9) | 0 (0.0) | 0 (0.0) | 4 (18.2) | 6 (25.0) |
| Hispanic, n (%) | 4 (28.6) | 6 (42.9) | 0 (0.0) | 0 (0.0) | 4 (18.2) | 6 (25.0) |
| BMI, med (IQR) | 26 (24–30) | 32 (25–41) | 29 (28–43) | 32 (28–38) | 28 (25–31) | 32 (27–40) |
| sCr (mg/dl), mean (SD) | ||||||
| At baseline | 0.96 (0.14) | 0.97 (0.17) | 1.80 (1.28) | 0.98 (0.85) | 1.26 (0.85) | 0.97 (0.15) |
| Day of urine sample collection | 3.60 (1.54) | 0.74 (0.30) | 4.21 (2.57) | 0.85 (0.21) | 3.82 (1.94) | 0.78 (0.26) |
| Fold change sCr, mean (SD) | 3.76 (1.59) | 0.77 (0.28) | 2.56 (1.11) | 0.87 (1.53) | 3.33 (1.53) | 0.81 (0.25) |
| Comorbidities, n (%) | ||||||
| Diabetes | 7 (50.0) | 4 (28.6) | 3 (37.5) | 2 (20.0) | 10 (45.5) | 6 (25.0) |
| Hypertension | 5 (35.7) | 8 (57.1) | 3 (37.5) | 4 (40.0) | 8 (36.4) | 12 (50.0) |
| Hyperlipidemia | 1 (7.1) | 4 (28.6) | 2 (25.0) | 3 (30.0) | 3 (13.6) | 7 (29.2) |
| CAD | 1 (7.1) | 0 (0.0) | 3 (37.5) | 0 (0.0) | 4 (18.2) | 0 (0.0) |
| CHF | 1 (7.1) | 0 (0.0) | 4 (50.0) | 0 (0.0) | 5 (22.7) | 0 (0.0) |
| Cancera | 3 (21.4) | 1 (7.1) | 1 (12.5) | 0 (0.0) | 4 (18.2) | 1 (4.2) |
| COPD or asthma | 3 (21.4) | 2 (14.3) | 1 (12.5) | 1 (10.0) | 4 (18.2) | 3 (12.5) |
| Baseline GFR <60 | 1 (7.1) | 0 (0.0) | 6 (75.0) | 0 (0.0) | 7 (31.8) | 0 (0.0) |
| Mechanical ventilation, n (%) | 14 (100.0) | 14 (100.0) | 2 (25.0) | 0 (0.0) | 16 (72.7) | 14 (58.3) |
| Death, n (%) | 6 (42.9) | 3 (21.4) | 4 (50.0) | 0 (0.0) | 10 (45.5) | 3 (12.5) |
AKI, acute kidney injury; BMI, body mass index; CAD, atherosclerotic coronary artery disease; CHF, congestive heart failure; COPD, chronic obstructive pulmonary disease; GFR, glomerular filtration rate; IQR, interquartile range; KDIGO, Kidney Disease Improving Global Outcomes; med, median; sCr, serum creatinine.
AKI was defined as meeting stage 2 or 3 criteria by KDIGO guidelines. GFR measured in ml/min per 1.73 m2.
a
Excludes nonmetastatic skin cancer.