TABLE 5:
Multivariable analysis of BMI at diagnosis and EFS and OS
| Covariable* | EFS | OS | ||||
|---|---|---|---|---|---|---|
| HR | 95%CI | p-value | HR | 95%CI | p-value | |
| BMI at Diagnosis | ||||||
| Not UW/OB | 1 | -- | -- | 1 | -- | -- |
| UW | 1.59 | 0.77–3.29 | 0.208 | 2.21 | 0.88–5.55 | 0.092 |
| OB | 2.32 | 1.12–4.83 | 0.024 | 3.69 | 1.47–9.26 | 0.006 |
| AYA, ≥15 years | 2.28 | 1.22–4.26 | 0.010 | 2.60 | 1.23–5.47 | 0.012 |
| Diagnosis | ||||||
| Germ Cell Tumor | 1 | -- | -- | 1 | -- | -- |
| Hepatoblastoma | 3.14 | 0.91–10.83 | 0.070 | 13.15 | 4.50–69.19 | 0.002 |
| CNS | 1.02 | 0.40–2.60 | 0.974 | 8.01 | 1.99–32.22 | 0.003 |
| Neuroblastoma | 0.65 | 0.23–1.83 | 0.415 | 4.87 | 1.03–23.15 | 0.046 |
| Osteosarcoma | 4.04 | 1.64–9.95 | 0.002 | 8.88 | 2.15–36.65 | 0.003 |
| Other | 3.15 | 0.91–11.00 | 0.071 | 16.76 | 3.22–87.17 | 0.001 |
| Dose Reduction | 1.74 | 0.94–3.24 | 0.080 | NS | ||
| Radiation Therapy | NS | 0.71 | 0.32–1.59 | 0.405 | ||
| Treatment-Related Toxicity | NS | 0.56 | 0.28–1.11 | 0.098 | ||
| ABMT** | 15.41 | 6.67–35.58 | <0.001 | 4.55 | 1.76–11.76 | 0.002 |
*
Individual multivariable models constructed for each endpoint using stepwise selection, see Methods.
**
Included as time-varying covariable.
EFS= event-free survival; OS= overall survival; HR= hazard ratio; CI= confidence interval; BMI= body mass index; UW= underweight; OB=obese; AYA= adolescent and young adult; ABMT= autologous bone marrow transplant; NS= not significant