Fig. 2. Drafting MetMap for 500 human cancer cell lines.
a, A schematic of the workflow using pan-cancer PRISM cell line pools for high-throughput metastatic potential profiling. Relative metastatic potential was quantified by deep sequencing of PRISM barcode abundance from tissue. The cancer lineage distribution of the profiled 500 cancer cell lines is presented, with each dot representing a cell line, and showing whether the cell line was derived from primary tumour or metastasis. b, Comparison of experimental conditions between MetMap500 and MetMap125. c, Scatter plots showing overall and organ-specific metastatic potential as determined in MetMap500 and MetMap125. Strong correlation is observed between the two experiments. Each dot represents a cell line. Cancer lineage is colour-coded as in a.